Bromodomains shake the hegemony of pan‐acetyl antibodies

Bromodomains shake the hegemony of pan-acetyl antibodies

Acetylation signaling pathways are involved in numerous cellular processes and are used as therapeutic targets in several disease contexts. However, acetylated proteins only represent a minor fraction of the full proteome, and the identification and quantification of acetylated sites remain a technological challenge. Currently, pan-acetyl antibodies are used to increase the abundance of acetyla...

The Hegemony of Play

In this paper, we introduce the concept of a “Hegemony of Play,” to critique the way in which a complex layering of technological, commercial and cultural power structures have dominated the development of the digital game industry over the past 35 years, creating an entrenched status quo which ignores the needs and desires of “minority” players such as women and “non-gamers,” Who in fact repre...

Shake-Shake regularization

The method introduced in this paper aims at helping deep learning practitioners faced with an overfit problem. The idea is to replace, in a multi-branch network, the standard summation of parallel branches with a stochastic affine combination. Applied to 3-branch residual networks, shake-shake regularization improves on the best single shot published results on CIFAR-10 and CIFAR100 by reaching...

The Threat of Regional Hegemony

The geopolitical importance of the Caspian region does not stem solely from its energy potential. Whether or not the area emerges as a major energy producer, its central geographical location, the considerable potential for regional instability and internal and interstate conflict, and the competition among external powers for influence all suggest that events in the region will shape the balan...

From ‘theories of Hegemony’ to ‘hegemony Analysis’ in International Relations